Structural alignment is a computational approach in bioinformatics utilised to determine the three-dimensional arrangement of proteins and other macromolecules. This technique, often used for protein sequence comparison, leverages the concept that molecules with similar structures may have analogous functions or evolutionary origins. It primarily involves assessing the geometric congruity of atomic coordinates in molecular structures.

The method gives rise to an understanding of functionally relevant regions, determining shared evolutionary ancestry, and predicting function of uncharacterised proteins. Its application spans various areas such as drug discovery and molecular modelling. Despite its utility, the process can be computationally intensive because it often requires comparing all pairs of residues between two structures.

In an effort to improve efficiency, different algorithms have been developed including DALI, CE, SSAP and TM-align. Each offers unique strengths in addressing specific structural alignment challenges. Structural alignment remains a cornerstone in the field of bioinformatics offering invaluable insight into the study of life on the molecular level.


Exact Match Keyword: Structural Alignment
N-gram Classification: Structural, Alignment
Substring Matches: Structure, Align
Category: Biomechanics
Search Intent: Information on aligning structures, particularly in the context of biology or engineering.
Semantic Relevance: Alignment of physical structures or components.
Parent Category: Engineering
Subcategories: Bioengineering, Mechanical Engineering
Synonyms: Structural Integration, Structure Alignment
Similar Searches: Structural Adjustment, Structural Realignment
Related Searches: Structural Analysis, Structural Design
Geographic Relevance:
– Global relevance due to its application in various fields worldwide.
– Commonly associated with research institutions and companies in countries with advanced engineering and biotechnological sectors.
Topically Relevant Entities:
– Protein structure alignment algorithms
– Vehicle chassis alignment techniques

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